Case Report

Ibuprofen Can Induce Syndrome of Inappropriate Diuresis in Healthy Young Patients

Table 1

Most common causes of SIADH.

Increased hypothalamic production of ADH

Neuropsychiatric disorders:
(i) infections: meningitis, encephalitis, abcess
(ii) vascular: thrombosis, subarachnoid or subdural haemorrhage, temporal arteritis, stroke
(iii) neoplasm: primary or metastatic
(iv) psychosis, delirium tremens
(v) other: Guillain-Barré syndrome, acute intermittent porphyria, autonomic neuropathy …

Drugs:
(i) intravenous cyclophosphamide
(ii) carbamazepine
(iii) vincristine or vinblastine
(iv) haloperidol
(v) bromocriptine
(vi) general anaesthesia
(vii) nicotine …

Pulmonary disease:
(i) pneumonia: viral, bacterial, fungal
(ii) tuberculosis
(iii) lung abscess, empyema
(iv) acute respiratory failure
(v) positive pressure ventilation
(vi) other: asthma, pneumothorax …

Postoperative patient

Severe nausea, pain, HIV infection

Idiopathic

Nohypothalamic (ectopic) production of ADH

Carcinoma: small cell carcinoma of lung, pancreas, thymus, prostate, uterus …

Lymphosarcoma, mesothelioma

Hodgkin’s disease, leukemia

Potentiation of ADH effect:
(i) chlorpropamide
(ii) carbamazepine
(iii) psychosis
(iv) prostaglandin-synthesis inhibitors (salicylates, NSAID)

Exogenous administration of ADH