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Increased hypothalamic production of ADH | |
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Neuropsychiatric disorders: | |
(i) infections: meningitis, encephalitis, abcess | |
(ii) vascular: thrombosis, subarachnoid or subdural haemorrhage, temporal arteritis, stroke | |
(iii) neoplasm: primary or metastatic | |
(iv) psychosis, delirium tremens | |
(v) other: Guillain-Barré syndrome, acute intermittent porphyria, autonomic neuropathy … | |
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Drugs: | |
(i) intravenous cyclophosphamide | |
(ii) carbamazepine | |
(iii) vincristine or vinblastine | |
(iv) haloperidol | |
(v) bromocriptine | |
(vi) general anaesthesia | |
(vii) nicotine … | |
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Pulmonary disease: | |
(i) pneumonia: viral, bacterial, fungal | |
(ii) tuberculosis | |
(iii) lung abscess, empyema | |
(iv) acute respiratory failure | |
(v) positive pressure ventilation | |
(vi) other: asthma, pneumothorax … | |
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Postoperative patient | |
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Severe nausea, pain, HIV infection | |
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Idiopathic | |
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Nohypothalamic (ectopic) production of ADH | |
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Carcinoma: small cell carcinoma of lung, pancreas, thymus, prostate, uterus … | |
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Lymphosarcoma, mesothelioma | |
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Hodgkin’s disease, leukemia | |
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Potentiation of ADH effect: | |
(i) chlorpropamide | |
(ii) carbamazepine | |
(iii) psychosis | |
(iv) prostaglandin-synthesis inhibitors (salicylates, NSAID) | |
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Exogenous administration of ADH | |
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