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Case Reports in Medicine
Volume 2013 (2013), Article ID 318358, 5 pages
http://dx.doi.org/10.1155/2013/318358
Case Report

Acute Systemic Viral Infection Masquerading as an Infiltrating Lymphoma in an Elderly Patient: A Case Report and Review of the Literature

1Division of Hematology and Oncology, The University of Arizona Cancer Center, 1515 N Campbell Avenue, Tucson, AZ 85724, USA
2Division of Hospital Medicine, Mayo Clinic, 5777 E Mayo Boulevard, Phoenix, AZ 85054, USA
3Division of Cardiology, Mayo Clinic, 5777 E Mayo Boulevard, Phoenix, AZ 85054, USA
4Department of Laboratory Medicine and Pathology, Mayo Clinic, 5777 E Mayo Boulevard, Phoenix, AZ 85054, USA
5Division of Infectious Diseases, Mayo Clinic, 5777 E Mayo Boulevard, Phoenix, AZ 85054, USA

Received 12 November 2012; Revised 13 January 2013; Accepted 15 January 2013

Academic Editor: Gianfranco D. Alpini

Copyright © 2013 Hani M. Babiker et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Primary Epstein-Barr virus (EBV) infection occurs mainly in adolescents and young adults, with more than 90% of adults having serological evidence of past infection. Primary infection in those over the age of 40 is associated with an atypical and often more severe presentation that can lead to more extensive and invasive, and often unnecessary, diagnostic testing. The incidence of severe EBV-related illness in older adults has been observed to be increasing in industrialized nations. The characteristic presentation of infectious mononucleosis (IM) syndrome in elderly patients (age > 65) is not clearly defined in the literature. Here, we describe a case of primary EBV infection in an 80-year-old female and review the literature regarding primary seroconversion in elderly patients.