318358.fig.001a
(a)
318358.fig.001b
(b)
Figure 1: Liver biopsy: (a) high power view of H&E-stained section of liver core biopsy showing focally prominent mixed inflammatory cell infiltrate comprised of small lymphocytes, plasma cells, neutrophils, and rare large cells with irregular nuclear contours and prominent eosinophilic nucleoli. Arrows point to large atypical lymphocytes (100x magnification). (b) EBV in situ hybridization analysis for the detection of EBV-encoded RNA (EBER) reveals abundant positive cells with dark nuclear staining, consistent with EBV infection. Arrow points to a large atypical EBV-positive cell (50x magnification).