Table 2: Common characteristics of infectious mononucleosis in elderly patients in comparison to younger patients.

Symptoms and signs
 Jaundice
 Prolonged fevers
 Hepatosplenomegaly
 Generalized lymphadenopathy
 Rashes
 Rarely neurological symptoms
Laboratory tests
 Lack of lymphocytosis
 Heterophile-negative antibody test (increases with age)
 Significant hyperbilirubinemia
 Elevation in liver function tests
 Positive EBV serology
Outcome
 Protracted duration of illness
 Prolonged hospitalizations
Common workup
 Blood tests including serologies
 Lymph nodes/liver biopsies
 Bone marrow aspiration and biopsies
 Imaging studies including MRI/CT scans
 Bronchoscopies
 ERCP

ERCP: endoscopic retrograde cholangiopancreatography. References: Horwitz et al., 1983 [3], and Axelrod and Finestone, 1990 [1].