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Case Reports in Medicine
Volume 2013 (2013), Article ID 591272, 4 pages
http://dx.doi.org/10.1155/2013/591272
Case Report

Short Interval Infield Sarcoma Development following Resection of Glioblastoma and Adjuvant Radiotherapy and Temozolomide

Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University and Department of Neurosurgery, McGill University Health Centre, 3801 University Avenue, 109 Montreal, QC, Canada H3A 2B4

Received 24 June 2013; Accepted 24 July 2013

Academic Editor: Lothar Bergmann

Copyright © 2013 Fahad E. Alotaibi and Kevin Petrecca. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. The development of 2 unassociated brain cancers in the same patient is a rare occurrence. Secondary cancers are generally thought to develop as an oncogenic consequence of the radiation therapy delivered to treat the primary cancers, always requiring a significant time interval between radiation treatment and secondary cancer development. Case Description. We report the development of an undifferentiated myxoid sarcoma only 13 months following radiation therapy for a glioblastoma. Conclusion. This case represents the shortest time interval reported between radiation therapy and secondary brain cancer development.