About this Journal Submit a Manuscript Table of Contents
Case Reports in Medicine
Volume 2013 (2013), Article ID 981232, 4 pages
http://dx.doi.org/10.1155/2013/981232
Case Report

Adult Onset Still’s Disease: A Case Report with a Rare Clinical Manifestation and Pathophysiological Correlations

1Interstitial Lung Disease Unit, Thoracic Medicine Department, University Hospital of Heraklion, 71110 Heraklion, Crete, Greece
2Department of Rheumatology, University Hospital of Heraklion, 71110 Heraklion, Crete, Greece

Received 5 October 2012; Accepted 20 December 2012

Academic Editor: Stephen P. Peters

Copyright © 2013 Katerina M. Antoniou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Adult-onset Still’s disease is an inflammatory multisystemic disease of unknown etiology. Pleuritis is the most common pulmonary manifestation and pleural effusions are usually exudates with a predominance of neutrophils. We report a case of an eosinophilic pleural effusion as a novel and hitherto unrecognized manifestation of active adult-onset Still’s disease. We also observed a marked NLRP3 inflammasome activation with increased production of IL-1β which coincided with the development and resolved upon remission of the pleural effusion suggesting a possible novel pathogenetic pathway for the development of pleural effusions in the context of the auto-inflammatory disorders.