Assessment of Premutation in Myotonic Dystrophy Type 1 Affected Family Members by TP-PCR and Genetic Counseling

Table 3

Molecular profile of the proband family members.

Proband	Relation with proband	Repeat size	Status	Family history
Case 1 (P2)	Sister (26 y); Father (50 y); Mother (45 y)	40; 15; 35	Asymptomatic; Normal; Asymptomatic	No
Case 2 (P7)	Father (45 y); Mother (41 y); Aunt (50 y); First cousin (28 y); Second cousin (26 y); Elder brother (20 y); Grandmother (74 y)	35; 40; 50; 50; 10; 20; 10	Asymptomatic; Asymptomatic; Asymptomatic; Asymptomatic; Normal; Normal; Normal	No
Case 3 (P8)	Father (60 y); Mother (58 y); Wife (38 y); Brother 1 (32 y); Brother 2 (28 y); Brother 3 (23 y); Daughter 1 (18 y); Daughter 2 (12 y); Son 1 (17 y)	20; 10; 10; 10; 15; 15; 40; 20; 15	Normal; Normal; Normal; Normal; Normal; Normal; Asymptomatic; Normal; Normal	No
Case 4 (P10)	Father (65 y); Mother (63 y); Wife (36 y); Brother 1 (41 y); Brother 2 (36 y); Son 1 (20 y); Son 2 (18 y)	20; 10; 20; 15; 10; 15; 25	Normal; Normal; Normal; Normal; Normal; Normal; Normal	No
Case 5 (P13)	Father (80 y); Wife (20 y)	40; 20	Asymptomatic; Normal	No