Case Report
Case of Thyrotoxic Periodic Paralysis in a Caucasian Male and Review of Literature
Table 1
Differences between thyrotoxic periodic paralysis (TPP) and familial hypokalemic periodic paralysis (FHPP).
| Characteristic | TPP | FHPP |
| Age | 20ā40 years | Usually less than 20 years | Heredity | Sporadic | Autosomal dominant | Ethnicity | Predominantly Asian | Predominantly Caucasians | Sex | Males more than females | Not specific | Hyperthyroidism | Present | Not present | Family history | Thyrotoxicosis | Hypokalemic paralysis | Genetic predisposition | Associated with SNPs of CACN1AS* in Asians | CACN1AS*, KCNE3*, and SCN4A* genes | Response to epinephrine | No change | Electromyography shows marked decrease in compound muscle action potential amplitude |
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ā*SNPs = single nucleotide polymorphisms. *CACN1AS = calcium channel alpha-1 subunit. *KCNE3 = potassium channel voltage-gated, Isk-related family, member 3. *SCN4A = sodium channel alpha-subunit.
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