Case Reports in Medicine / 2014 / Article / Tab 3 / Case Report
Chronic Hepatitis C Therapy in Liver Cirrhosis Complicated by Telaprevir-Induced DRESS Table 3 RegiSCAR scoring system for DRESS classification. Final scores 2-3 = Possible, 4-5 = Probable, and >5 = Definite case of DRESS [
9 ,
10 ]. Bold cells are positive findings.
Score Patient A Patient B −1 0 1 2 −1 0 1 2 Fever ≥38.5°C No/U Yes — — No/U Yes — — Enlarged lymph nodes — No/U Yes — — No/U Yes — Eosinophilia No/U No/U Eosinophils — — 0.7–1.49 × 109 L−1 >1.5 × 109 L−1 — — 0.7–1.49 × >1.5 × 109 L−1 Eosinophils, if leukocytes < 4.0 × 109 L−1 — — 10–19.9% ≥20% — — 10–19.9% ≥20% Atypical lymphocytes — No/U Yes — — No/U — — Skin involvement: Skin rash extent (% body surface area) — No/U >50% — — No/U >50% — Skin rash suggesting DRESS No U Yes — No U Yes — Biopsy suggesting DRESS No Yes/U — — No Yes/U — — Organ involvement: Liver — No/U Yes — — No/U Yes — Kidney — No/U Yes — — No/U Yes — Muscle/heart — No/U Yes — — No/U Yes — Pancreas — No/U Yes — — No/U Yes — Other organ — No/U Yes — — No/U Yes — Resolution ≥15 days No/U Yes — — No/U Yes — — Evaluation of other potential causes: Antinuclear antibody — — — — — — — Blood culture Serology for HAV/HBV/HCV Chlamydia/mycoplasma If none positive and ≥3 of above negative Yes Yes Total Score 8 8
