Acute Rhabdomyolysis Associated with Coadministration of Levofloxacin and Simvastatin in a Patient with Normal Renal Function
Table 1
Naranjo’s probability scale for our case.
Naranjo’s algorithm questions
Answer
Score
(1) Are there previous conclusive reports of this reaction?
Yes
+1
(2) Did the adverse event appear when the drug was administered?
Yes
+2
(3) Did the adverse reaction improve when the drug was discontinued or a specific antagonist was administered?
Yes
+1
(4) Did the adverse reaction reappear when the drug was readministered?
Do not know
0
(5) Are there alternative causes (or other drugs) that could on their own explain the adverse reaction?
Yes
−1
(6) Did the adverse reaction reappear when a placebo was given?
No
+1
(7) Was the drug detected in the blood (or other fluids) in concentrations known to be toxic?
No
0
(8) Was the reaction more severe when the dose was increased or less severe when the dose was decreased?
Yes
+1
(9) Did the patient have a similar reaction to the same or similar drugs in any previous exposure?
Do not know
0
(10) Was the adverse event confirmed by any objective evidence?
No
0
Total score:
5
The total score calculated from this table defines the category to which an adverse event belongs to. The categories are defined as shown below: definite (certain): >8; probable: total score 5–8; possible: total score 1–4; doubtful (unlikely): total score <1.