645045.fig.003a
(a)
645045.fig.003b
(b)
645045.fig.003c
(c)
Figure 3: (a) The upper left panel is the macroscopic image of the right fallopian tube which is markedly distended and shows a polypoid mucosal mass (right tube). Small yellowish deposits are also seen in the mucosa. The upper middle and right panels show chronic xanthomatous salpingitis with lymphoid and foam cell infiltration. The middle panel is the Haematoxylin and Eosin stained section with an original magnification of ×10 and the right panel which is the also Haematoxylin and Eosin stained section with an original magnification of ×40. The left panel of the middle row shows tubal epithelium near the polypoid lesion with high grade dysplasia (Haematoxylin and Eosin stained section, original magnification ×40). The middle panel of the middle row also shows tubal epithelium near the polypoid lesion with high grade dysplasia (Haematoxylin and Eosin stained section, original magnification of ×60). The right panel of the middle row shows the polypoid mass (Haematoxylin and Eosin stained section, original magnification of ×4). The left panel of the lower row is a vimentin stain which stains the stroma and the dysplastic epithelium but not the normal tubal epithelium (immunoperoxidase stain, original magnification ×60). The middle panel of the lower row is immunoperoxidase stain for oestrogen receptor with an original magnification ×40. The dysplastic tubal epithelium is strongly positive (upper part) and normal tubal epithelium is weakly positive (lower part). The right panel of the lower row is immunoperoxidase stain for CA125 with an original magnification of ×20. The epithelium (normal and dysplastic) shows luminal staining. (b) The upper panels are macroscopic images showing a normal ovary but a distended fallopian tube (left tube). The external surface is shown in the left panel and cut surface is shown in the right panel. The tube shows multiple fibrous bands. The middle panels show features of chronic salpingitis with disorganisation of tubal mucosal folds, infiltration by inflammatory cells, fibrosis, and loss of muscle. The left panel of the middle row is the Haematoxylin and Eosin stained section with an original magnification of ×4 and the right panel of the middle row is also the Haematoxylin and Eosin stained section but at original magnification of ×10. The lower panels also show features of chronic salpingitis with focal epithelial atypia in the centre of the images. The left panel of the middle row is the Haematoxylin and Eosin stained section with an original magnification of ×40 and the right panel of the middle row is also the Haematoxylin and Eosin stained section but at original magnification of ×60. (c) The left upper panels are macroscopic images of the uterus with a somewhat polypoid endometrial lesion (uterus). The right shows an endometrioid carcinoma which is infiltrating the endocervix (Haematoxylin and Eosin stained section, original magnification of ×4). The left panel of the middle row is a vimentin stain which shows strong stromal and epithelial expression (immunoperoxidase stain, original magnification of ×10). The right panel of the middle row is immunoperoxidase stain for oestrogen receptor with an original magnification of ×20. Positive staining is observed in the stroma as well as the epithelium. The left panel of the lower row is CD10 which stains the normal endometrium (lower part) but not the carcinoma (immunoperoxidase stain, original magnification of ×20). The right panel of the lower row is CA125 which shows luminal staining in the malignant glands (immunoperoxidase stain, original magnification of ×20).