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Case Reports in Medicine
Volume 2014 (2014), Article ID 678035, 8 pages
Case Report

Multifocal Metachronous Giant Cell Tumor: Case Report and Review of the Literature

Department of Orthopedic Surgery, Hotel Dieu de France Hospital, Alfred Naccache Street, Achrafieh, P.O. Box 166830, Beirut, Lebanon

Received 14 September 2013; Revised 13 November 2013; Accepted 5 December 2013; Published 5 January 2014

Academic Editor: Johny Verschakelen

Copyright © 2014 B. Ghostine et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Introduction. Giant cell tumors (GCTs) of bone are known for their local aggressiveness and high recurrence rate. There are rare cases of multicentric GCT and most are synchronous. We herein review metachronous multicentric GCT reported in the literature. Material and Methods. A MEDLINE, Cochrane, and Google Scholar search was done to collect all cases of multicentric metachronous GCT specifying the clinical, radiological, and histological characteristics of each location and its treatment. Results. A total of 37 multifocal giant cell tumors were found in the literature. 68% of cases of multicentric giant cell tumors occur in less than 4 years following treatment of the first lesion. Thirty-seven cases of multifocal metachronous GCT were identified in the literature until 2012. Patients with multicentric GCT tend to be younger averaging 23. There is a slight female predominance in metachronous GCT. The most common site of the primary GCT is around the knee followed by wrist and hand and feet. Recurrence rate of multicentric GCT is 28.5%. Conclusion. Multicentric giant cell tumor is rare. The correct diagnosis relies on correlation of clinical and radiographic findings with confirmation of the diagnosis by histopathologic examination.