Late Onset Combined Immunodeficiency Presenting with Recurrent Pneumocystis jiroveci Pneumonia
Table 2
Measurements of lymphocyte subpopulations via flow cytometry during hospital stay and at follow-up.
Hospital stay
Follow-up
13/10/2006
22/11/2006
15/06/2007
27/09/2007
15/12/2008
WBC (lower cut-off: >4000 cells/L)
2200
3920
4250
n/a
5000
Lymphocytes (lower cut-off: >1000 cells/μL)
320
510
720
n/a
740
CD4+ T (n.l: 663–1477 cells/μL, 42–58%)
52/16.4%
46/9.0%
46/6.34%
4.6%
23/3.1%
CD8+ T (n.l: 342–754 cells/μL, 22–30%)
26/8.0%
337/66%
466/64.5%
70.3%
555/74.9%
CD4/CD8 ratio
2.0
0.1
0.1
<0.1
<0.1
CD3+ T (n.l: 1500–1900 cells/μL, 69.5–81.3%)
82/25.5%
357/70%
486/67.5%
77.5%
575/77.7%
CD19+ B (n.l: 150–400 cells/μL, 6.80–16.4%)
5/1.5%
5/1%
103/14.3%
8.5%
71/9.6%
NK (n.l: 100–300 cells/μL, 3.30–12.5%)
192/60.3%
77/15%
311/43.2%
19.9%
78 /10.5%
CD4+ CD45RA+ T
n/a
0.27%
0.4%
n/a
n/a
CD4+ CD45RO+ T
n/a
8.5%
5.2%
n/a
n/a
WBC: white blood cells, CD4+ CD45RA+ T: naïve CD4+ T lymphocytes, CD4+ CD45RO+ T: memory CD4+ T lymphocytes, n/a: not available, and n.l: normal limits. CD4+ T and CD8+ T, CD3+ T, CD19+ B, and NK lymphocytes are depicted in absolute values and percentage (%) of blood lymphocytes. CD4+ CD45RA+ T and CD4+ CD45RO+ T lymphocytes were calculated in the total number of lymphocytes of the sample for which data is shown.
