Case Report
Sunitinib Induced Thrombotic Thrombocytopenic Purpura in addition to Severe Hypothyroidism: A Case Report and Review of the Literature
Table 1
Summary of cases of TTP associated with sunitinib in the literature.
| Author | Age/sex | Cancer | Dose/time of onset | Presentation | Treatment | Outcome |
| Kapiteijn et al. [12] | 54 years/female | GIST* | 50 mg/day 6th cycle | Loss of vision, seizure, hypertension, and RPLS | Withdrawal and plasma exchange | Recovery |
|
Frangié et al. [7] | 70 years/male | RCC† | ND‡/3 weeks | Asthenia, hypertension, and renal insufficiency | Withdrawal and plasma exchange | Recovery |
| Choi et al. [14] | 62 years/female | RCC | 50 mg/day 3 weeks | Hematuria, proteinuria, and hypertension | Withdrawal and plasma exchange | Recovery |
| This case | 73 years/female | RCC | 50 mg/day 4 weeks | Asthenia, edema, renal insufficiency, and anemia | Withdrawal and plasma exchange | Recovery |
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Gastrointestinal stromal tumor. Rapidly progressing posterior leucoencephalopathy. †Renal cell carcinoma. ‡Not described.
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