Sunitinib Induced Thrombotic Thrombocytopenic Purpura in addition to Severe Hypothyroidism: A Case Report and Review of the Literature

Table 1

Summary of cases of TTP associated with sunitinib in the literature.

Author	Age/sex	Cancer	Dose/time of onset	Presentation	Treatment	Outcome
Kapiteijn et al. [12]	54 years/female	GIST*	50 mg/day; 6th cycle	Loss of vision, seizure, hypertension, and RPLS	Withdrawal and plasma exchange	Recovery
Frangié et al. [7]	70 years/male	RCC^†	ND^‡/3 weeks	Asthenia, hypertension, and renal insufficiency	Withdrawal and plasma exchange	Recovery
Choi et al. [14]	62 years/female	RCC	50 mg/day; 3 weeks	Hematuria, proteinuria, and; hypertension	Withdrawal and plasma exchange	Recovery
This case	73 years/female	RCC	50 mg/day; 4 weeks	Asthenia, edema, renal; insufficiency, and anemia	Withdrawal and plasma exchange	Recovery

Gastrointestinal stromal tumor.
Rapidly progressing posterior leucoencephalopathy.
^†Renal cell carcinoma.
^‡Not described.