Case Report

Clozapine-Induced Late Agranulocytosis and Severe Neutropenia Complicated with Streptococcus pneumonia, Venous Thromboembolism, and Allergic Vasculitis in Treatment-Resistant Female Psychosis

Table 1

Main investigations of the patient performed during hospitalization.

Laboratory testResultNormal range

White blood cell count 11004–10 * 103/L
Neutrophils 0.042.2–75.2%
Lymphocytes 96.520.5–51.1%
Monocytes2.7 1.7–9.3%
Hematocrit 28.236–46%
Hemoglobin9.5 12–14 g/dL
Platelets264140–440 * 103/L
Reticulocytes0.00.1–1.5%
Prothrombin time14.29.6–11.6 sec
Activated partial-thromboplastin time33.3526–39 sec
Serum sodium135 135–144 mEq/L
Serum potassium 3.3 3.2–4.8 mEq/L
Blood urea nitrogen1115–43 mg/dL
Creatinine 0.6 0.6–1.1 mg/dL
Aspartate aminotransferase (AST)295–34 IU/L
Alanine aminotransferase (ALT)480–55 IU/L
Gamma-glutamyltransferase (γGT)65 9–36 IU/L
Lactate dehydrogenase 276 134–279 IU/L
Serum amylase 14 25–125 IU/L
Immunoglobulin (Ig) G11.37–16 g/L
Immunoglobulin (Ig) A1.750.8–4.5 g/L
Immunoglobulin (Ig) M1.02 0.4–2.5 g/L
Complement component C31.320.8–1.5 g/L
Complement component C40.340.1–0.4 g/L
Rheumatoid factor17.30–20 IU/mL
C-reactive protein (CRP)238.6<5 mg/L
Erythrocyte sedimentation rate970–22 mm/Hour
D-dimers10.29<0.5 mg/L