Case Report

Cutaneous and Gastrointestinal Symptoms in Two Patients with Systemic Mastocytosis Successfully Treated with Omalizumab

Table 1

Studies of mastocytosis treated with omalizumab.

StudyPatients ()DoseEffect

Systemic mastocytosis
 Carter et al., 2007 [7]2300 mg/4 weeksPatient I: no further anaphylactic episodes
Patient II: reduced gastrointestinal and anaphylactic episodes
 Pitt et al., 2010 [8]1300 mg/4 weeksNo further anaphylactic episodes
 Kontou-Fili et al., 2010 [9]1300 mg/4 weeksNo further anaphylactic episodes
 Douglass et al., 2010 [10]1150 mg/4 weeksNo further anaphylactic episodes or cardiac arrest
 Paraskevopoulos et al., 2013 [11] 1300 mg/4 weeksNo further anaphylactic episodes
 Kibsgaard et al., 2014 [12]1300 mg/4 weeksNo further anaphylactic episodes
Cutaneous mastocytosis
 Siebenhaar et al., 2007 [13]1150 mg/4 weeksReduced cutaneous symptoms
 Matito et al., 2013 [14]1450 mg/4 weeksReduced cutaneous symptoms
 Sokol et al., 2014 [15]1375 mg/2 weeksReduced cutaneous symptoms