An Unexpected Interaction between Sofosbuvir/Ledipasvir and Atorvastatin and Colchicine Causing Rhabdomyolysis in a Patient with Impaired Renal Function
Table 2
Naranjo probability scale. Total scores range from −4 to +13; the reaction is considered definite if the score is 9 or higher, probable if 5 to 8, possible if 1 to 4, and doubtful if 0 or less.
Yes
No
Do not know
Are there previous conclusive reports of this reaction?
+1
0
0
Did the adverse event appear after the drug was given?
+2
−1
0
Did the adverse reaction improve when the drug was discontinued or a specific antagonist was given?
+1
0
0
Did the adverse reaction reappear upon readministering the drug?
+2
−2
0
Were there other possible causes for the reaction?
−1
+2
0
Did the adverse reaction reappear upon administration of placebo?
−1
+1
0
Was the drug detected in the blood or were other fluids detected in toxic concentrations?
+1
0
0
Was the reaction worsened upon increasing the dose? Or was the reaction lessened upon decreasing the dose?
+1
0
0
Did the patient have a similar reaction to the drug or a related agent in the past?
+1
0
0
Was the adverse event confirmed by any other objective evidence?
