Miliary Histoplasmosis in a Patient with Rheumatoid Arthritis

Table 1

Comparison of cases of miliary histoplasmosis.

Year	Reference	Age (yrs)	Sex	Comorbidities	Symptoms	Chest imaging	Initial diagnosis	Final diagnosis	Method of diagnosis	Outcome
1983	Tong et al. [12]	45	F	None	Progressive weight loss, abdominal swelling, intermittent fever, nocturnal sweating	Chest X-ray: diffuse pulmonary miliary shadows with scattered nodular lesions	Miliary tuberculosis	Disseminated histoplasmosis with pulmonary involvement	Autopsy	Death
2012	Cormier et al. [13]	37	M	None	Fever, abdominal pain, diarrhea, weight loss, asthenia	Chest X-ray: diffuse bilateral opacities with a 1-2 mm radius simulating miliary tuberculosis	Miliary tuberculosis	Disseminated histoplasmosis with pulmonary involvement	BAL	Death
2013	Cottle et al. [14] 13 students with respiratory symptoms. 5 with confirmed histoplasmosis. 2 cases described here	22	F	None	Fever, dry cough, chest pain, shortness of breath with exertion	Chest X-ray: diffuse miliary shadowing	Miliary tuberculosis	Pulmonary histoplasmosis	Serum antibodies
		21	M	None	Productive cough, shortness of breath, night sweats	CT: mediastinal lymphadenopathy, bibasilar consolidation, bilateral pulmonary micronodules	Miliary tuberculosis	Pulmonary histoplasmosis	Serum antibodies	Survived
2015	Lakshman et al. [15]	25	F	HIV	Fevers, chills, cough, hematemesis, melena	CT: miliary nodules in both lungs	Disseminated tuberculosis	Disseminated histoplasmosis with pulmonary involvement	Bone marrow biopsy	Survived
2017	Our case	52	M	RA	Fevers, chills, cough, fatigue, night sweats, nausea, vomiting	CT: diffuse micronodularity	Miliary coccidioidomycosis	Miliary histoplasmosis	Left upper lobe tissue culture	Survived