Prolonged Recovery Time from Zoledronic Acid Induced Acute Tubular Necrosis: A Case Report and Review of the Literature
Figure 1
Light microscopy renal biopsy results (H&E stain). Renal biopsy showing changes of ATN. (a) Proximal tubules are mildly dilated and simplified in appearance. Scattered tubules contain denuded and necrotic epithelial cells (arrows). Patchy very mild interstitial inflammation is seen in the right upper-hand corner. Glomeruli (G) exhibit only mild mesangial prominence; art: distal artery (H&E stain, original magnification = 100x). (b) Higher magnification reveals attenuation of proximal tubular epithelium with loss or disruption of brush border. The interstitium exhibits edema superimposed upon mild fibrosis (H&E stain, original magnification = 400x).
