Nephrotic Syndrome Secondary to Proliferative Glomerulonephritis with Monoclonal Immunoglobulin Deposits of Lambda Light Chain
Figure 2
Light microscopic finding of kidney biopsy. PAS at 400x shows glomerulus with globally increased mesangial matrix and cellularity and segmental attachment to Bowman’s capsule (a). The glomerular capillary loops show patchy endocapillary proliferation and focal mononuclear cell infiltration. No necrosis or crescents are seen in glomeruli, and the interstitium shows extensive fibrosis and patchy tubular atrophy. PAS at 200x demonstrates tubules containing intraluminal casts with smooth borders and flattening and sloughing of tubular epithelial cells (b).
