Blockade of Alternative Complement Pathway in Dense Deposit Disease
Figure 1
(a) Type II membranoproliferative glomerulonephritis characterized by mesangial matrix and cellular increases is responsible for a lobular accentuation associated with a diffuse and intense staining of the peripheral basement membrane (periodic acid-Schiff [PAS], magnification [G]: ×200). (b) The diffuse and intense staining of the peripheral basement membrane indicates the presence of dense deposit material (PAS, G ×2000). (c) Immunofluorescence techniques show segmental pseudo linear and granular IgM deposits along the peripheral capillary wall (fluorescein isothiocyanate anti-IgM, G ×100).
