Therapeutic Benefits of Tocilizumab Vary in Different Organs of a Patient with AA Amyloidosis
Figure 3
Renal biopsy. (a) Hematoxylin-eosin staining shows that approximately 40% of the glomeruli were globally sclerotic; however, the remaining glomeruli were minimally obliterated by mesangial matrix expansion, and homogeneous and eosinophilic deposits were evident along the capillary walls. Small arteries are thickened by eosinophilic deposits, and tubules are focally atrophic. (b) The deposits reveal positive reactions to Congo red. (c) Immunoperoxidase staining confirmed that the deposits included amyloid A protein. (d) After 4 years of tocilizumab treatments, Congo red staining revealed no regression of the amyloid deposition.
