Collapsing Glomerulopathy in a Child with Galloway-Mowat Syndrome

Figure 2

(a) Light microscopy shows wrinkling and collapse of the glomerular basement membranes accompanied by hypertrophied and hyperplastic podocytes forming pseudocrescents (Jones’ methenamine silver stain, ×400). (b) Electron microscopy shows diffuse swelling in the endothelial layer and podocytes with electron-lucent transport vesicles (circle), diffuse foot process effacement, and wrinkling, irregular thinning, and thickening of the glomerular basement membranes (Electromicrograph, bar = 2 µm). (c) At higher magnification, swollen podocytes with increased organelles, protein resorption droplets (long arrows), and a disrupted actin cytoskeleton (asterisk). The glomerular basement membranes had a radiolucent fibrillary appearance (short arrows), and the lamina densa had disappeared or was disrupted in many areas in the glomerular basement membrane (Electromicrograph, bar = 1 µm).

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