Case Report

Atypical Haemolytic Uraemic Syndrome Associated with Clostridium difficile Infection Successfully Treated with Eculizumab

Table 1

Published reports of C. difficile-associated aHUS.

ReferenceAge/sexKidneyClinical featuresTreatmentDialysisOutcome

[3]51/femaleNativeWatery diarrhoea, confusionVancomycinNoRecovery
[4]46/femaleNativeBloody diarrhoea, vomitingMetronidazole, plasmapheresisYesRecovery
[5]62/femaleNativeWatery diarrhoeaMetronidazole, plasmapheresis, steroidsYesRecovery
[6]73/femaleNativeWatery diarrhoea, respiratory distress, chills, anuriaMetronidazole, steroidsYesRecovery
[7]29/femaleTransplantDiarrhoea, decreased urine outputVancomycinYesComplete recovery
[7]52/femaleTransplantFever, diarrhoea, nausea, vomitingMetronidazole, plasmapheresisYesAllograft failure and transplant nephrectomy
[7]63/femaleNativeBloody diarrhoea, fever, confusionMetronidazole, vancomycin, plasmapheresisYesPartial recovery
Current case46/maleNativeWatery diarrhoea, anuriaPlasmapheresis, metronidazole, vancomycin and eculizumabYesRecovery