Case Report
Severe Hypocalcemia and Dramatic Increase in Parathyroid Hormone after Denosumab in a Dialysis Patient: A Case Report and Review of the Literature
Table 1
Laboratory data at baseline and after denosumab therapy.
| Laboratory parameters | Before treatment | After denosumab therapy | Reference range | Day 10 | Day 15 | Day 30 |
| Corrected Calcium (mg/dL) | 9.9 | 6.9 | 8.7 | 9.3 | 8.4 – 10.2 |
| Phosphorus (mg/dl) | 3.8 | 3.1 | 3.6 | 3.6 | 2.5 – 5.0 |
| Intact PTH (pg/ml) | 442 | 2601 | 799 | 349 | 150 – 300 (Caucasian Dialysis patients) |
| Alkaline phosphatase (U/L) | 96 | 84 | 54 | 49 | 34- 104 |
| 25-OH Vitamin D (ng/ml) | 35 | _ | _ | _ | 30 - 100 |
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