Case Report

Severe Hypocalcemia and Resulting Seizure Caused by Vitamin D Deficiency in an Older Patient Receiving Phenytoin: Eldecalcitol and Maxacalcitol Ointment as Potential Therapeutic Options for Hypocalcemia

Table 1

Patient's laboratory data on admission.

Reference range

Complete blood count
White blood cells10 390/μL
Neutrophils90.6%
Red blood cells  × 104342/μL
Hemoglobin10.8 g/dL
Platelets × 10426.5/μL

Serum biochemistry
Total protein6.2 g/dL
Albumin3.1 g/dL
Blood urea nitrogen13.8 mg/dL
Creatinine0.44 mg/dL
Uric acid1.9 mg/dL
Total bilirubin0.3 mg/dL
Aspartate aminotransferase74 U/L
Alanine aminotransferase36 U/L
Alkaline phosphatase463 U/L
γ‐Glutamyl transpeptidase33 U/L
Lactate dehydrogenase729 U/L
Total cholesterol186 mg/dL
Amylase158 U/L
LDL‐cholesterol96 mg/dL
Sodium131 mEq/L
Potassium3.1 mEq/L
Chloride92 mEq/L
Calcium3.7 mg/dL
Phosphate1.6 mg/dL
Magnesium2.97 mg/dL
Hemoglobin A1c (NGSP)5.6%

Coagulation
PT‐INR1.20
APTT32.1 sec

Immunological testing
C‐reactive protein1.67 mg/dL
Procalcitonin0.52 mg/dL

Endocrinology
Intact PTH386.8 pg/mL10–65
Calcitriol27 pg/mL20–60
25‐hydroxyvitamin D5.4 ng/mL9.0–33.9
TRACP‐5b116 mU/mL120–420
BAP31.3 μg/L3.8–22.6
Osteocalcin10.2 ng/mL; 2.5–13
Calcitonin<0.5 pg/mL26.2–49.0

Arterial blood gas
pH7.458
PaO281.7 mmHg
PaCO233.9 mmHg
HCO323.7 mmol/L
Ca2+0.55 mmol/L

Urinary biochemistry
Urinary creatinine121.7 mg/dL
Urinary calcium0.8 mg/dL
Urinary phosphate22.6 mg/dL

Abbreviations: APTT, activated partial thrombin time; BAP, bone‐type alkaline phosphatase; Ca2+, ionized calcium; HCO3, hydrogen carbonate; LDL, low‐density lipoprotein; NGSP, national glycohemoglobin standardization program; PaCO2, partial pressure of arterial carbon dioxide; PaO2, partial pressure of arterial oxygen; PT‐INR, prothrombin time‐international normalized ratio; PTH, parathyroid hormone; TRACP‐5b, tartrate‐resistant acid phosphatase 5b.