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Case Reports in Neurological Medicine
Volume 2013 (2013), Article ID 254950, 3 pages
http://dx.doi.org/10.1155/2013/254950
Case Report

Dupuytren's Contracture Cosegregation with Limb-Girdle Muscle Dystrophy

1Latvian Biomedical Research and Study Centre, Ratsupites Street 1, Riga 1067, Latvia
2Children Clinical University Hospital, Medical Genetics Clinic, Riga 1004, Latvia
3Pauls Stradins Clinical University Hospital, Riga 1002, Latvia
4Children Clinical University Hospital, Neurology Clinic, Riga 1004, Latvia

Received 28 May 2013; Accepted 18 July 2013

Academic Editors: D. B. Fee, F. C. Henderson, and J. C. Kattah

Copyright © 2013 Baiba Lace et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Limb-girdle muscular dystrophies (LGMDs) is a heterogeneous group of muscular dystrophies that mostly affect the pelvic and shoulder girdle muscle groups. We report here a case of neuromuscular disease associated with Dupuytren's contracture, which has never been described before as cosegregating with an autosomal dominant type of inheritance. Dupuytren's contracture is a common disease, especially in Northern Europe. Comorbid conditions associated with Dupuytren's contracture are repetitive trauma to the hands, diabetes, and seizures, but it has never before been associated with neuromuscular disease. We hypothesize that patients may harbor mutations in genes with functions related to neuromuscular disease and Dupuytren's contracture development.