Demyelinating Disease following Anti-TNFa Treatment: A Causal or Coincidental Association? Report of Four Cases and Review of the Literature

<table> (a) and (b) Axial FLAIR brain MRI images of the fourth patient demonstrating multiple periventricular and subcortical lesions at the frontal, parietal, and temporal lobes (black arrows). (c) Axial T1-weighted brain MRI image showing gadolinium ring enhancement in one of the subcortical lesions (white arrow) and two subcortical black holes (white dotted arrows) (e) Sagittal T2- and (f) T1-weighted MRI of the cervical spine showing one hyperintense lesion at the C4-C5 level with gadolinium enhancement (white arrowheads).</table>

Case Reports in Neurological Medicine

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Figure 4: Demyelinating Disease following Anti-TNFa Treatment: A Causal or Coincidental Association? Report of Four Cases and Review of the Literature 

Figure 4 | Demyelinating Disease following Anti-TNFa Treatment: A Causal or Coincidental Association? Report of Four Cases and Review of the Literature 