Multiple Sclerosis and Oligodendroglioma: An Exceptional Association

Table 1

Reported cases of MS and pure oligodendroglioma cooccurrence.

Author		Age at MS onset	Age at tumor diagnosis	MS course	Tumor clinical presentation	MRI main features (other than typical MS findings)	Histopathology
Khan et al. [5]		43	51	RRMS	No symptoms (suspicion based on routine MRI)	3 cm enhancing lesion involving both white and gray matter in the right parietal lobe*	Monomorphic neoplasm composed of oligodendrocytes, GFAP positive, and CD68 negative
Green et al. [6]	Case	34	50	RRMS	No symptoms (suspicion based on routine MRI)	Nonenhancing mass lesion involving white matter in the right temporoparietal area, with some sulcal effacement of the overlying cortex*	Microcystic low grade oligodendroglioma
	Case	44?	44?	N/A	Seizures and monocular inferior left scotoma	Right temporal lobe lesion with some mass effect*	Grade 2 oligodendroglioma
Giordana et al. [3]		34	42	PPMS	N/A	Bilateral frontal lesion, involving anterior corpus callosum	Unclear grade oligodendroglioma, not contiguous with MS lesions
Rao et al. [4]		N/A	65	N/A	N/A	Diffuse lesion (right > left) across corpus callosum	Oligodendroglioma with spotty calcification, ring lesions, contiguous with MS plaques
Barnard and Jellinek [2]		28	43	RR/SC MS	N/A	Mass lesion at the right temporal lobe	“Polymorphic” oligodendroglioma with mitotic figures and central necrosis
de la Lama et al. [7]		26	37	RRMS	Seizures	Large subcortical lesion at the right frontal lobe, poorly enhancing, causing mass effect and midline shifting to the left*	Tumoural proliferation with homogeneous nuclei and clear cytoplasms, not contiguous with MS plaques—grade C oligodendroglioma (Smith classification)

*Enlargement from previously known lesion in routine MRI.
N/A: not available; RRMS: relapsing-remitting multiple sclerosis; SC: secondary progressive.