Case Report

Clinical Pathway in the Treatment of Nocardial Brain Abscesses following Systemic Infections

Table 1

Summary of patient characteristics.

Case 1Case 2Case 3

Age402451

GenderFFM

OccupationHousewifeAmanuensisWorker of pottery

ComorbiditiesSystemic sclerosis with
Raynaud’s syndrome
(pulmonary tuberculosis, Herpes zoster, inactive)
Systemic lupus erythematosusBronchial asthma, pneumoconiosis, pulmonary tuberculosis, inactive, pseudomembrane colitis,
colon adenocarcinoma

Immunosuppression agentSteroidsSteroidsSteroids

Initial symptoms and signsFever;
unsteady gait
Right facial spasm with dull pain;
slurred speech;
afebrile leukocytosis
Fever with leukocytosis;
quadriplegia;
seizure attacks

Abscess numberMultipleMultipleMultiple

Abscess size (in the largest diameter, mm)103030

Abscess progression YesYesYes

Abscess localizationL, F, P B, T, OB, T, F, P

Following treatmentChange to second-line antibioticsChange to second-line antibiotics;
stereotaxic aspiration;
craniotomy
Refused craniotomy

3-month outcomeRight hemiplegiaHomonymous hemianopia;
alexia
Death

1-year outcomeDeathHomonymous hemianopia;
alexia
Death

Other sites involvedNilNilNil

aDuration from symptoms onset to diagnosis (day)14738

Antibiotics for abscessesOxacillin; ceftriaxone; imipenem;
sulfamethoxazole/trimethoprim
Sulfamethoxazole/trimethoprim;
meropenem trihydrate;
amikacin
Sulfamethoxazole/trimethoprim

Duration of antibiotics use (day)752944

Surgical interventionCraniotomy with guided sonography for the aspiration of the abscessesCraniotomy with guided sonography for the aspiration of the abscessesStereotaxic aspiration

Time from onset of neurological symptoms to laboratory proven results.
M: male; F: female; L: left; B: bilateral; F: frontal; P: parietal; T: temporal; O: occipital.