JC Virus PCR Detection Is Not Infallible: A Fulminant Case of Progressive Multifocal Leukoencephalopathy with False-Negative Cerebrospinal Fluid Studies despite Progressive Clinical Course and Radiological Findings

<div>Top row: MRI head, axial T2-FLAIR. Bottom row: MRI head, T1-post gadolinium contrast in same chronological order (right to left). Note the prominent progressive asymmetric subcortical T2-FLAIR signal abnormality over the course of 12 weeks with noted lack of pathological enhancement during the same time window. (Left) image: week 1, middle: week 6, and right: week 12. Lumbar puncture was obtained after the second MRI (middle).</div>

Case Reports in Neurological Medicine

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Figure 1: JC Virus PCR Detection Is Not Infallible: A Fulminant Case of Progressive Multifocal Leukoencephalopathy with False-Negative Cerebrospinal Fluid Studies despite Progressive Clinical Course and Radiological Findings 

Figure 1 | JC Virus PCR Detection Is Not Infallible: A Fulminant Case of Progressive Multifocal Leukoencephalopathy with False-Negative Cerebrospinal Fluid Studies despite Progressive Clinical Course and Radiological Findings 