JC Virus PCR Detection Is Not Infallible: A Fulminant Case of Progressive Multifocal Leukoencephalopathy with False-Negative Cerebrospinal Fluid Studies despite Progressive Clinical Course and Radiological Findings

<div>(a) PML gross pathology finding, right frontoparietal white matter lesion (black arrow). The subcortical whiter matter shows an irregular disruption measuring 1 × 1.5 cm. (b) Viral inclusions in an enlarged oligodendroglial nucleus (black arrow). (c) Bizarre reactive astrocyte with enlarged nucleus and prominent nucleolus. (d) Perivascular cuffing by lymphocytes. (e) Luxol Fast Blue/H&amp;E stain showing an intranuclear inclusion (black arrow) and numerous foamy macrophages containing myelin debris (red arrow). (f) Immunocytochemistry using target-antibody against SV40, showing numerous positively stained oligodendroglia.</div>

Case Reports in Neurological Medicine

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Figure 2: JC Virus PCR Detection Is Not Infallible: A Fulminant Case of Progressive Multifocal Leukoencephalopathy with False-Negative Cerebrospinal Fluid Studies despite Progressive Clinical Course and Radiological Findings 

Figure 2 | JC Virus PCR Detection Is Not Infallible: A Fulminant Case of Progressive Multifocal Leukoencephalopathy with False-Negative Cerebrospinal Fluid Studies despite Progressive Clinical Course and Radiological Findings 