About this Journal Submit a Manuscript Table of Contents
Case Reports in Obstetrics and Gynecology
Volume 2013 (2013), Article ID 492754, 2 pages
http://dx.doi.org/10.1155/2013/492754
Case Report

A Fibroid or Cancer? A Rare Case of Mixed Choriocarcinoma and Epithelioid Trophoblastic Tumour

1Royal Hospital for Women, Barker Street, Randwick, NSW 2031, Australia
2Gyneacological Cancer Centre, Royal Hospital for Women, Randwick, NSW 2031, Australia

Received 20 March 2013; Accepted 12 April 2013

Academic Editors: M. Furuhashi, P. Kovacs, P. McGovern, and M. A. Osmanagaoglu

Copyright © 2013 Wan Yu Luk and Michael Friedlander. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. Gestational trophoblastic disease (GTD) is a rare complication of pregnancy which is characterised by abnormal growth of the trophoblasts at the placental site. It is categorised into benign and malignant forms, which include hydatidiform moles (HMs) and gestational trophoblastic neoplasia (GTN), respectively. A mixed choriocarcinoma (CC) and epithelioid trophoblastic tumour (ETT) is an extremely rare subgroup of GTN, which is a highly curable but aggressive form of malignancy. Case. We report a case of mixed CC and ETT in a 41-year-old patient who presented with a 2-year history of menorrhagia and fibroid uterus in the absence of previous history of molar pregnancy. She had a 12-year interval between the antecedent pregnancy and presentation. She was treated with intensive regimen of adjuvant chemotherapy, etoposide, methotrexate, and actinomycin-D with etoposide and cisplatin (EMA-EP). She has remained disease free for more than 5 years. Conclusion. This case highlights the importance of considering GTN as one of the differential diagnoses value of β-HCG in patients presented with menorrhagia and growing fibroids.