Case Report

Management of Membranous Glomerulonephritis in Pregnancy: A Multidisciplinary Challenge

Table 2

Case reports of membranous glomerulonephritis in pregnancy.

AuthorDisease historyTreatmentMaternal outcomeFetal outcome

Katzir et al. [3], 200423 y/o with known MGNMethylprednisolone pulse therapy
Oral prednisolone
Proteinuria, HTN
Preeclampsia at 34 weeks
HTN, proteinuria resolved following delivery
C/S at 34 weeks, secondary failed induction for preeclampsia
Male, 2,090 g

Sebestyen et al. [9], 200833 y/o with known MGN
Previous pregnancy with preeclampsia at 36 weeks
Methylprednisolone pulse therapy
Oral prednisolone Azathioprine
Deterioration of creatinine clearance, low serum total protein, increasing edema
Three months after delivery, maternal condition went into complete remission
IUGR
C/S at 33 weeks due to IUGR and deterioration of maternal renal function
Male, 1,160 g

Aoshima et al. [10], 201337 y/o, no history of MGN
Previous normal pregnancy
Methylprednisolone pulse therapy
Oral prednisolone
Increasing edema
Increasing proteinuria 5.28 g/day
Diagnosed with MGN at after pregnancy termination
Symptoms resolved after termination
Elective termination due to worsening symptoms at 21 weeks

Ope-Adenuga et al., index patient28 y/o, no history of MGN
First pregnancy: uncontrolled HTN
Second pregnancy: uncomplicated
Third pregnancy: possible preeclampsia, fetal demise at 29 weeks
Fourth pregnancy: index case
Tacrolimus
Oral prednisone
Increasing edema, worsening of renal function, increased proteinuria
Diagnosed with MGN at 25-week gestation
Symptoms improved during treatment and completely resolved after delivery
Preterm labor at 30 weeks
Female, 1021 g