| | Author(s) | Mother’s age, gravidity and parity, and gestational age at admission | Mode of delivery | Anesthesia | Hypertensive treatment | Anticonvulsant treatment | Complications |
| | Cohen et al. [7] (1976) | 37 yo, G3P1, term | Spontaneous vaginal delivery | Spinal anesthesia | Furosemide and methydopa | Magnesium sulfate (IM injection) | Within 10 minutes of IM magnesium sulfate, the patient had a myasthenic crisis but improved quickly with 1.0 g calcium gluconate, 0.4 mg atropine, and 10.0 mg edrophonium. | | Duff [8] (1979) | 26 yo, G2P1,
37 weeks | Cesarean section | General anesthesia (thiopentone, scoline, pancuronium, and nitrous oxide) | Poor control with methyldopa, diazoxide, reserpine, and furosemide | Diazepam “for sedation” | The patient required 16 hours of ventilator support because of respiratory insufficiency after general anesthesia. | | Duff (1979) | 36 yo, G2P1,
36 weeks | Vaginal delivery after labor induction | Spinal anesthesia | Ephedrine (no evidence for use currently) | None reported | MG did not improve in the postpartum period, so the patient was started on prednisone. The patient was discharged five weeks postpartum with improvement of MG symptoms. | | Brogan and Corcoran [9] (1983) | 37 yo, G1P0,
32 weeks | Cesarean section | Spinal anesthesia | None reported | None reported | No complications noted. | | Bashuk and Krendel [10] (1990) | 19 yo, G1P0, term | Spontaneous vaginal delivery | None noted | None reported | Magnesium sulfate IV (4.0 g once) and IM (5.0 g q4h) | Weakness worsened with each IM injection and she became quadriplegic. Once treatment was stopped, she regained muscle strength within a day. |
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| | Author(s) | Mother’s age, gravidity and parity, and gestational age at admission | Mode of delivery | Anesthesia | Hypertensive treatment | Anticonvulsant treatment | Clinical presentation |
| | Benshushan et al. [11] (1994) | 31 yo, G1P0,
31 weeks | Vaginal delivery after labor induction and artificial rupture of membranes | None noted | Methyldopa and hydralazine, later using furosemide with little diuresis | None reported | Delivery complicated by hemorrhage. The patient was transferred to the ICU for dyspnea, oliguria, and weakness where treatment was started with dopamine, furosemide, IV corticosteroids, and IV pyridostigmine. The patient was discharged ten days later. | | Di Spiezio Sardo et al. [12] | 27 yo, G2P0,
37 weeks | Cesarean section | Spinal anesthesia | Methyldopa | None reported | The patient was diagnosed with severe preeclampsia complicated by HELLP syndrome. The patient was discharged on day six postpartum. | | Hamaoui and Mercado [13] (2009) | 31 yo, G7P3,
27 weeks | Cesarean section | Spinal anesthesia (bupivacaine) | Hydralazine, metoprolol, losartan, amlodipine, and labetaol. Labetalol drip controlled BP. | None reported | Three days postpartum, the patient developed HELLP syndrome and myasthenic exacerbation. | | Ozcan et al. [14] (2015) | 34 yo, G1P0,
36 weeks | Cesarean section | Spinal anesthesia (bupivacaine and fentanyl) | Enalapril | None reported | The patient became bradycardic (42 bpm) after spinal anesthesia, requiring atropine and ephedrine to resolve. Postpartum period required enalapril, with increased dose of pyridostigmine and IV immunoglobulin to resolve symptoms. The patient was discharged 8 days after the Cesarean section. | | Sikka et al. [15] (2015) | 25 yo, G1P0,
36 weeks | Cesarean section | Spinal anesthesia | None reported | None reported | No complications noted. |
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