Prenatal and Peripartum Management of Patients with Hypofibrinogenemia Resulted in Two Successful Deliveries

Table 1

Characteristics of inherited fibrinogen disorders.

	Afibrinogenemia	Hypofibrinogenemia	Dysfibrinogenemia
Transmission	AR	AD/AR	AD
Fibrinogen level (mg/dL)	<10	70–100	Lower limit of normal
Laboratory	PT-APTT-TT	PT: normal or prolonged	PT-APTT: normal
	Markedly prolonged	APTT: normal
Symptoms	Umbilical cord bleeding	No symptoms; Abnormal bleeding; after trauma or operation	No symptoms; Abnormal bleeding; after trauma or operation; Thrombosis
	Recurrent abortion
	Cutaneous bleeding
	Intracranial bleeding
	Gastrointestinal bleeding
	Hypermenorrhea

AR; Autosomal recessive, AD; Autosomal dominant, PT; prothrombin time,
APTT; actinated partial thromboplastin time, TT; thrombin time.