A Rare Presentation of Stage IV Large Cell Neuroendocrine Carcinoma of the Cervix with Metastasis to the Cranium

Figure 3

Cervical biopsy (40X): the infiltrative carcinoma is largely distorted by crush artifact. A preserved intravascular focus of carcinoma (arrow and inset A, 500X) is characterized by cells with variable clear to eosinophilic cytoplasm, round to oval nuclei, delicate chromatin, and punctate nucleoli. Scattered apoptotic cells are noted. The tumor cells are strongly immunoreactive for neuroendocrine markers synaptophysin (inset B, 400X).