Successful Management of the Fetal Severe Anemia Associated with Jra Alloimmunization by Intrauterine Transfusion of Jr(a+) Red Blood Cells

Table 2

Theclinical details and outcomes of the reported cases of Jra alloimmunization, including the present case.

Case	GA at first PUBS or IUT (weeks)	MCA-PSV at first PUBS (MoM)	Hb (g/dL)/Hct (%)/T-bil (mg/dL) at first PUBS	Number of IUTs	Type of blood transfusion	GA at birth (weeks)	Interval between the last IUT and birth (weeks)	Hydrops fetalis	Hb (g/dL)/Hct (%)/T-bil (mg/dL) at birth	Maximum anti-Jra titer	Neonatal transfusion	Neonatal outcome
Cases with IUT (n = 6)
Present case	30	>1.55	3.5/ 9.9/ N/A	2	Jr(a+)	35	5	-	9.2/ 28.4/ 1.7	512	+	Alive
Case 2 (unrelated)	29	>1.55	5.3/ 15.7/ 1.4	1	Jr(a-)	37	8	-	9.4/ 29.0/ 1.1	256	-	Alive
Ishihara et al. [11]	30	>1.55	3.5/ 7.9/ 1.0	4	Jr(a-)	35	1	+	7.2/ N/A/ 1.0	512	+	Alive
Fujita et al. [4]	30	>1.5	8.5/ 26.8/ N/A	1	Jr(a-)	37	7	-	11.8/ 35.4/ 2.0	512	-	Alive
Aikou et al. [12]	30	>1.5	5.4/ 15.7/ 2.3	1	Jr(a-)	38	8	-	10.8/ 31.8/ 2.1	32	-	Alive
Yahara et al. [13]	27	N/A	3.4/ 11.4/ 1.9	2	Jr(a-)	37	6	+	12.2/ 37.0/ 1.0	16	-	Alive
Cases without IUT (n = 4)
Sasamoto et al. [14]	-	-	-	0	-	33	-	-	8.2/ 25.4/ 0.9	1024	-	Alive
Peyrard et al. [10]	-	-	-	0	-	36	-	+	6.4/ N/A/ 2.5	1024	+	Neonatal death
Endo et al. [7]	-	-	-	0	-	37	-	-	8.4/ 25.8/ 1.9	256	-	Alive
Masumoto et al. [9]	-	-	-	0	-	37	-	-	11.5/ N/A/ N/A	64	-	Alive

GA: gestational age; Hb: hemoglobin; Hct: hematocrit; PUBS: percutaneous umbilical cord blood sampling; IUT: intrauterine transfusion; T-bil: total bilirubin; N/A: not available. Case 2 is unrelated to ours. The clinical data of case 2 was provided by the Department of Fetal-Maternal Medicine, Nagara Medical Center.