Pheochromocytoma/Paraganglioma (PPGL): A Misdiagnosed Cause of Hypertension during Pregnancy

Table 1

Clinical data from the two patients diagnosed with PPGL during pregnancy.

	Case 1	Case 2
Age at diagnosis	25 years	22 years
Gestational age	31 weeks	18 weeks
Clinical history and symptoms	Hypertension, hyperglycemia, sweating, palpitations since before pregnancy	Hypertension during paroxysms
Plasma NMN/MN	10x ULN/normal	—
Urinary NMN/MN	—	10x ULN/normal
Molecular study	None GPV detected	MAX deletion exon 1-3
Surgical management	C-section at 32^nd week, no previous adrenergic blockade; laparoscopic excision 4 mo later	Laparoscopic tumor excision at 23 wks, 15 days after alpha-adrenergic blockade
Maternal and fetal complications	Hypertensive crisis during C-section; no further clinical repercussions	None

NMN = normetanephrine; MN = metanephrine; ULN = upper limit of normal.