Figure 2: Histopathology of Primary JPA and sGBM. Tumor at original diagnosis reveals a hypercellular biphasic pattern of solid and cystic neoplasm with bland nuclei, and microvascular proliferation consistent with a diagnosis of low-grade glioma (a) (40x magnification, hematoxylin-eosin stained) Posterior fossa tumor 9 years after initial diagnosis reveals nuclear atypia with numerous mitosis, vascular proliferation, and pseudopalisading necrosis consistent with a diagnosis of glioblastoma multiforme (b) (20x magnification, hematoxylin-eosin stained).