Case Report

HHV8-Negative Primary Effusion Lymphoma of B-Cell Lineage: Two Cases and a Comprehensive Review of the Literature

Table 1

Summary of clinical characteristics of 48 patients with HHV8-negative effusion lymphomas of B-cell lineage.

Characteristics Number of patients (%)

Age (n = 48)
 Age > 60 10 (20.8)
 Age < 60 38 (79.2)
Sex (n = 48)
 Male 29 (60.4)
 Female 19 (39.6)
EBV status (n = 47)
 Positive 10 (21.3)
 Negative 37 (78.7)
HCV status (n = 36)
 Positive 8 (22.2)
 Negative 28 (77.8)
Site(s) involved (n = 41)
 Pleura 27 (65.9)
 Peritoneum 16 (39.0)
 Pericardium 15 (36.6)
Treatment (n = 48)
 No chemotherapy17 (35.42)
 CHOP 11 (22.92)
 CHOP + R 3 (6.25)
 THP-CVP6 (12.5)
 THP-CVP + R4 (8.3)
 Other regimens 6 (12.5)
 Unknown 1 (2.0)
Outcome
 At 6 months (n = 45)
  Dead (10/45) 22.2%
  Alive (35/45) 77.8%
 At 1 year ( )
  Dead (14/36) 38.9%
  Alive (22/36) 61.1%

Abbreviations: CHOP: cyclophosphamide, doxorubicin, vincristine, prednisone; R: Rituximab; THP-CVP-pirarubicin, cyclophosphamide, vincristine, prednisone; EBV: Epstein-Barr virus, HCV: hepatitis C virus.