Case Reports in Oncological Medicine / 2014 / Article / Tab 1 / Case Report
Multiple Cutaneous Angiosarcomas after Breast Conserving Surgery and Bilateral Adjuvant Radiotherapy: An Unusual Case and Review of the Literature Table 1 Major published studies concerning angiosarcomas of the breast after radiation.
Study Age (yrs) Time to BA (mo) Surgery Surgical margins Nuclear grade Time to first recurrence (mo) Site of first recurrence Treatment at first recurrence Followup Chahin et al., 2001 [22 ] 76 11 SM Negative High 3 Bilateral BA None Died 2 mo later Feigenberg et al., 2002 [23 ] 72 77 SM Negative Low 2 Surgical scar RT (50 Gy) NED (39 mo after RT) Feigenberg et al., 2002 [23 ] 73 66 SM Close High 1 Surgical scar RT + WLE NED (38 mo after RT) Feigenberg et al., 2002 [23 ] 76 56 SM Positive Low 1.5 Surgical scar and flap RT NED (22 mo after RT) Hildebrandt et al., 2001 [24 ] 79 66 SM Negative Low 4 Local recurrence WLE Alive with disease (23 mo) Majeski et al., 2000 [19 ] 73 63 SM Negative — 26 Local recurrence WLE NED Mills et al., 2002 [25 ] 77 96 SM Negative High — None — NED (14 mo) Polgár et al., 2001 [26 ] 71 72 WLE Negative Int 3 Local recurrence RM NED (36 mo) Sener et al., 2001 [27 ] 73 132 SM Negative High 3 Bilateral BA RT Dead (9 mo) Solin et al., 2001 [28 ] — 75 SM — — — None — NED (86 mo)
Vesoulis and Cunliffe, 2000 [29 ] 45 96 SM — — — — — No followup Wang et al., 2009 [30 ] 87 108 SM Negative Int 9 Local recurrence — Alive with disease Rao et al., 2003 [31 ] 59 168 RM Negative High — — — NED (41 mo) Esler-Brauer et al., 2007 [32 ] 67 60 RM Negative Int — — — NED (45 mo) Meattini, 2014, present study 71 23 WLE Negative Low 9 Bilateral BA Bilateral RM Alive with disease (23 mo)
BC: breast cancer; BA: breast angiosarcomas; SM: simple mastectomy; RM: radical mastectomy; WLE: wide local excision; Int: intermediate; RT: radiation therapy; NED: no evidence of disease; mo: months; yrs: years.