Multiple Cutaneous Angiosarcomas after Breast Conserving Surgery and Bilateral Adjuvant Radiotherapy: An Unusual Case and Review of the Literature

Table 1

Major published studies concerning angiosarcomas of the breast after radiation.

Study	Age; (yrs)	Time to BA; (mo)	Surgery	Surgical margins	Nuclear grade	Time to first recurrence (mo)	Site of; first recurrence	Treatment at; first recurrence	Followup
Chahin et al., 2001 [22]	76	11	SM	Negative	High	3	Bilateral BA	None	Died 2 mo later
Feigenberg et al., 2002 [23]	72	77	SM	Negative	Low	2	Surgical scar	RT (50 Gy)	NED (39 mo after RT)
Feigenberg et al., 2002 [23]	73	66	SM	Close	High	1	Surgical scar	RT + WLE	NED (38 mo after RT)
Feigenberg et al., 2002 [23]	76	56	SM	Positive	Low	1.5	Surgical scar and flap	RT	NED (22 mo after RT)
Hildebrandt et al., 2001 [24]	79	66	SM	Negative	Low	4	Local recurrence	WLE	Alive with disease (23 mo)
Majeski et al., 2000 [19]	73	63	SM	Negative	—	26	Local recurrence	WLE	NED
Mills et al., 2002 [25]	77	96	SM	Negative	High	—	None	—	NED (14 mo)
Polgár et al., 2001 [26]	71	72	WLE	Negative	Int	3	Local recurrence	RM	NED (36 mo)
Sener et al., 2001 [27]	73	132	SM	Negative	High	3	Bilateral BA	RT	Dead (9 mo)
Solin et al., 2001 [28]	—	75	SM	—	—	—	None	—	NED (86 mo)
Vesoulis and Cunliffe, 2000 [29]	45	96	SM	—	—	—	—	—	No followup
Wang et al., 2009 [30]	87	108	SM	Negative	Int	9	Local recurrence	—	Alive with disease
Rao et al., 2003 [31]	59	168	RM	Negative	High	—	—	—	NED (41 mo)
Esler-Brauer et al., 2007 [32]	67	60	RM	Negative	Int	—	—	—	NED (45 mo)
Meattini, 2014, present study	71	23	WLE	Negative	Low	9	Bilateral BA	Bilateral RM	Alive with disease (23 mo)

BC: breast cancer; BA: breast angiosarcomas; SM: simple mastectomy; RM: radical mastectomy; WLE: wide local excision; Int: intermediate; RT: radiation therapy; NED: no evidence of disease; mo: months; yrs: years.