A Unique Case of Malignant Pleuropericardial Effusion: HHV-8-Unrelated PEL-Like Lymphoma—A Case Report and Review of the Literature

Table 1

HHV-8 negative, HIV, EBV, and Hep C negative PEL-like lymphomas reported.

Reference	Age/sex	Site	Immunophenotyping	Therapy	Outcome
Terasaki et al. [15]	99/F	Pleural, pericardium	CD19, CD20, CD5, CD25, IgM, IgD	Drainage	Alive at 16 months
Wang et al. [16]	79/M	Pleural	CD45, CD20, CD79a, bcl-2, bcl-6, MUM1	Pleurodesis	Alive at 55 months
Terasaki et al. [15]	85/M	Pleural, pericardium	CD20	None	Alive at 11 months
Inoue et al. [17]	67/F	Pericardium	CD20, CD79a	CHOP, MEPP, and DEVIC	Expired in 16 months
Kagoya et al. [18]	74/M	Pericardium	CD20	RCHOP	Expired in 7 months
Takahashi et al. [19]	73/M	Pleural, pericardium, and peritoneum	CD20	CHOP	Alive at 12 months
Terasaki et al. [20]	68/M	Pleural	CD20, CD79a	RCHOP	Alive at 22 months
Fujisawa et al. [21]	69/M	Pleural, pericardium	CD19, CD20, CD5, bcl2, Cyclin D1	THP-COP	Expired in 5 months
Youngster et al. [22]	88/M	Pleural	CD20, CD30, CD79a, CD45	RCHOP	Alive at 11 months
Hermine et al. [11]	52/F	Pleural, pericardium	CD19, CD20, CD22, CD45, HLA-DR	Not mentioned	Not mentioned
Ohshima et al. [14]	75/M	Pleural	CD19, CD20, HLA-DR	CHOP	Expired in 15 months
Ohshima et al.* [14]	76/M	Pleural	CD19, CD20, CD10, HLA-DR	None	Alive at 6 months
Ohshima et al.* [14]	32/F	Peritoneum	CD10, CD19, CD20, HLA-DR	CHOP and PBSCT	Alive at 13 months
Ohshima et al.* [14]	81/M	Pleural	CD19, CD20, CD10, CD5, HLA-DR	None	Alive at 2 months
Shimazaki et al. [23]	90/F	Pleural, pericardium, and peritoneum	CD20, CD79a, BCL-2	None	Expired in five months
Inoue et al. [24]	70/F	Pleural, pericardium	CD19, CD20, CD22, CD24, CD8, CD10, CD38, HLA DR	CHOP and sobuzoxane	Alive at 30 months
Fujiwara et al. [25]	75/F	Pericardium	CD20, CD79a	CHOP	Alive at 36 months
Nemr et al.* [26]	92/F	Pleural	CD20, CD45, BCL-2	None	Expired in 2 months
Nakamura et al. [27]	51/M	Scrotum	CD45, CD19, CD20, CD79a	Carboplatin, etoposide, mitoxantrone, prednisone, and RT	Alive at 8 months
Saini et al. [28]	87/F	Pleural	CD19, CD45, CD20, CD79a	Pleurodesis	Alive at 21 months
Saini et al. [28]	82/F	Pleural	CD20, bcl6, MUM1, PAX 5	Pleural drainage	Expired in 13 months
Matsumoto et al. [29]	90/M	Pleural	CD19, CD20, CD30	R + THP-COP	Alive at 38 months
Matsumoto et al. [29]	87/F	Pleural	CD20, CD30	Rituximab	Alive at 32 months
Our patient	76/M	Pleural/pericardium	CD-20, CD-10, BCL-2, MIB 1	None	Alive at 14 months

∗Status of Hepatitis C is not described.
Currently, there is no standard chemotherapeutic regimen for its treatment. When employed, chemotherapy has largely been based on CHOP regimen.