Progressive Multifocal Leukoencephalopathy with Negative JC Virus PCR following Treatment of Follicular Lymphoma: Implications for Biologics in the Era of Targeted Cancer Therapy

<div>Axial images of MRI of the brain showing multiple confluent foci of T2-weighted FLAIR hyperintensity involving the inferior right and left frontal lobes, as well as periventricular regions (a-b). Hyperintensities are also seen in the left corona radiata (c-d). These areas are representative CNS demyelination. Several foci had restricted diffusion. There was no flow-limiting stenosis, occlusion, or aneurysm in intracranial and extracranial circulations. Images progress superiorly to inferiorly from (a) through (d).</div>

Case Reports in Oncological Medicine

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Figure 1: Progressive Multifocal Leukoencephalopathy with Negative JC Virus PCR following Treatment of Follicular Lymphoma: Implications for Biologics in the Era of Targeted Cancer Therapy 

Figure 1 | Progressive Multifocal Leukoencephalopathy with Negative JC Virus PCR following Treatment of Follicular Lymphoma: Implications for Biologics in the Era of Targeted Cancer Therapy 