Progressive Multifocal Leukoencephalopathy with Negative JC Virus PCR following Treatment of Follicular Lymphoma: Implications for Biologics in the Era of Targeted Cancer Therapy

<div>Frontal lobe biopsy of the brain showing chromatic margination in oligodendrocytes (a), perivascular mixed chronic inflammation (b), and SV40 antigen positivity (c) consistent with JC virus infection. The aforementioned histological findings are demarcated by green arrows.</div>

Case Reports in Oncological Medicine

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Figure 5

Figure 5: Progressive Multifocal Leukoencephalopathy with Negative JC Virus PCR following Treatment of Follicular Lymphoma: Implications for Biologics in the Era of Targeted Cancer Therapy 

Figure 5 | Progressive Multifocal Leukoencephalopathy with Negative JC Virus PCR following Treatment of Follicular Lymphoma: Implications for Biologics in the Era of Targeted Cancer Therapy 