Is It Safe to Restart Antivascular Endothelial Growth Factor Therapy in Patients with Renal Cell Carcinoma after Cardiac Ischemia?

Table 1

Summary of ischemic events and interventions on anti-VEGF TKIs.

Case	1	2	3
Age at diagnosis (years)	54	51	63
TKI during cardiac event	Sunitinib	Axitinib	Axitinib
Ischemic event	MI	Angina	Angina
Intervention	Stent ×3	Stent ×4	Stent ×6
Known underlying CAD	No	No	No
Days on TKI before the event	2256	1384	885
Duration of break during cardiac event (days)	77	9	28
Days on the same TKI after the event	721	450	1080
LVEF after the event (%)	55	60	55
CHF at any time	No	No	No
Subsequent ischemia	No	No	Yes

VEGF: vascular endothelial growth factor; TKI: tyrosine kinase inhibitor; MI: myocardial infarction; CAD: coronary cardiac disease; CABG: coronary artery bypass graft; LVEF: left ventricular ejection fraction; CHF: congestive heart failure.