Capecitabine Induced Multifocal Leukoencephalopathy: Do We Have Always to Switch off the Chemotherapy?

Figure 1

T2-weighted and FLAIR MRI revealed the presence of a high signal intensity mainly in periventricular and subcortical white matter of the bilateral cerebral hemispheres (a, b) and pons (d), without gadolinium enhancement on T1-weighted sequence (c). ADC maps showed increased signal intensity suggestive of vasogenic edema (e). The high signal intensity detected in the deep white matter of bilateral cerebral hemispheres was significantly reduced one year after the onset of symptoms under metronomic chemotherapy ((f) axial T2-sequence; ((g) and (h)) axial FLAIR-sequence).

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