Case Report
Pulmonary Fibrosis after Pegylated Liposomal Doxorubicin in Elderly Patient with Cutaneous Angiosarcoma
Table 1
Comparison between the present case report and the others reported in the literature.
| | Age | Sex | Risk factors | Tumor | Cancer treatment | Dose of cancer treatment | Timing of symptoms development | CT scan evidence | Treatment of ILD | Outcome |
| Mazzotta et al. | 77 y | F | Systemic sclerosis; thoracic radiation therapy | Angiosarcoma | PLD | PLD: 40 mg/m2 d1 q28 | 8 weeks after the first administration | Confluent bilateral ground glass areas | Steroids and antibiotics | Fatal |
| Huober et al. [4] | 53 y | F | None | Breast cancer | PLD + Bevacizumab | PLD: 20 mg/m2 d1 q14; Bevacizumab: 10 mg/m2 d1 q14 | 6 weeks after the first administration | Ground glass areas | Steroids | Resolved |
|
Mark and Thürlimann [5] | 70 y | F | Previous chemotherapy; thoracic radiation therapy | Breast cancer | PLD | PLD: 20 mg/m2 d1 q14 | 6 weeks after the first administration | Bilaterally pronounced alveolitic changes | Steroids and antibiotics | Fatal |
| Inaba et al. [6] | 48 y | F | Previous chemotherapy | Ovarian cancer | PLD | PLD: 50 mg/m2 d1 q28 | 8 weeks after the first administration | Ground glass areas | Steroids and antibiotics | Resolved |
| Nevadunsky et al. [7] | 57 y | F | Previous chemotherapy | Uterine papillary serous carcinoma | PLD | PLD: 40 mg/m2 d1 q28 | 12 weeks after the first administration | Diffuse airspace disease | Steroids and antibiotics | Fatal |
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