Case Report

Pulmonary Fibrosis after Pegylated Liposomal Doxorubicin in Elderly Patient with Cutaneous Angiosarcoma

Table 1

Comparison between the present case report and the others reported in the literature.

AgeSexRisk factorsTumorCancer treatmentDose of cancer treatmentTiming of symptoms developmentCT scan evidenceTreatment of ILDOutcome

Mazzotta et al.77 yFSystemic sclerosis; thoracic radiation therapyAngiosarcomaPLDPLD: 40 mg/m2 d1 q288 weeks after the first administrationConfluent bilateral ground glass areasSteroids and antibioticsFatal

Huober et al. [4]53 yFNoneBreast cancerPLD + BevacizumabPLD: 20 mg/m2 d1 q14;
Bevacizumab: 10 mg/m2 d1 q14
6 weeks after the first administrationGround glass areasSteroidsResolved

Mark and Thürlimann [5]70 yFPrevious chemotherapy; thoracic radiation therapyBreast cancerPLDPLD: 20 mg/m2 d1 q146 weeks after the first administrationBilaterally pronounced alveolitic changes Steroids and antibioticsFatal

Inaba et al. [6]48 yFPrevious chemotherapyOvarian cancerPLDPLD: 50 mg/m2 d1 q288 weeks after the first administration Ground glass areasSteroids and antibioticsResolved

Nevadunsky et al. [7]57 yFPrevious chemotherapyUterine papillary serous carcinomaPLDPLD: 40 mg/m2 d1 q2812 weeks after the first administrationDiffuse airspace diseaseSteroids and antibiotics Fatal